Nouailles

We are happy to have contributed to the study of our cooperation partners at the Paul-Ehrlich-Institut, where we describe vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T_H2-biased immunization.

Ebenig, A. et al. (2022). Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after TH2-biased immunization. Cell reports 40.

Welcome to our new lab member Karen Hoffmann! We are excited to have on board her knowledge and expertise on novel organotypic human lung models for studying bacterial infections.

Congratulations to Peter Pennitz, our Leipzig collaborator Holger Kirsten and of course the rest of the dream team for publishing work on the cross-species comparison of single-cell transcriptomes from human (Homo sapiens), African green monkey (Chlorocebus sabaeus), pig (Sus domesticus), hamster (Mesocricetus auratus), rat (Rattus norvegicus) and mouse (Mus musculus) lung cells!

By employing techniques such as RNA velocity and intercellular communication based on ligand-receptor co-expression, we have demonstrated a workflow for interspecies data integration, applied a single unified gene nomenclature, performed cell-specific clustering and identified marker genes for each species.

Pennitz, P. et al. (2022). A pulmonologist’s guide to perform and analyse cross-species single lung cell transcriptomics. European respiratory review : an official journal of the European Respiratory Society 31.

The Berlin hamster consortium has made an important step towards better transcriptional evaluation of COVID-19 disease, thanks to their successful genome annotation of the Roborovski Dwarf Hamster; an animal model for severe/critical COVID-19. Special compliments to Sandro Andreotti and Emanuel Wyler!

You find a detailed description about the methodology on GitHub.

Andreotti, S. et al. (2022). De Novo-Whole Genome Assembly of the Roborovski Dwarf Hamster (Phodopus roborovskii) Genome: An Animal Model for Severe/Critical COVID-19. Genome biology and evolution 14.

We are delighted that the pre-print of our recent COVID-19 study titled „A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants“ has attracted widespread attention in various public media outlets. We hope to continue engaging with and communicating our scientific findings to the general public. Below you can find some of the press releases relating to our study:

berliner-zeitung.de, tagesspiegel.de, zeit.de, pharmazeutische-zeitung.de, spektrum.de, deutschlandfunk.de, news-medical.net, mdr.de, blick.ch, faz.net

The preprint of our COVID-19 study titled „A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants“ is now available here. Many thanks to our collaboration partners at Freie Universität Berlin, BIMSB, MDC and BIH to help spearhead this major contribution to the field of vaccine research.

Nouailles, G. et al. A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants (2022).