Respiratory tract infections represent the leading cause of infection-related mortality worldwide. Community-acquired pneumonias are caused by e.g. Streptococcus pneumoniae as well as atypical intracellular bacteria such as Legionella pneumophila, whereas gram-negative bacteria such as Pseudomonas aeruginosa and Klebsiella pneumoniae are often associated with hospital-acquired pneumonias. An appropriate immune response that controls the invading microbes is vital for preserving organ function and preventing spread of infection. However, overwhelming inflammation can also lead to tissue damage (acute lung injury, acute respiratory distress syndrome), which is associated with high mortality.
We are studying how the immune system senses infection, how it defends the host against extracellular and intracellular pathogens, and how it is influenced by environmental factors, comorbidities and medical interventions. Our research aims to contribute to the development of new prophylactic and therapeutic strategies to protect high-risk patients from community-acquired and nosocomial lung infections.
