Nouailles

Together with our collaborators at the MDC and FU Berlin, we describe the effectiveness of a combination therapy involving anti-SARS-CoV-2 monoclonal antibodies and dexamethasone for treatment of COVID-19 in two distinct hamster models. Using single-cell transcriptomics, we identified a subpopulation of neutrophils responsive to dexamethasone treatment and characterized the synergistic anti-viral effects of monoclonal antibody and dexamethasone combination therapy.

You find the press release at the Charité-Website.

Wyler, E. et al. (2022). Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics. Molecular therapy : the journal of the American Society of Gene Therapy 30.

Safe travels to Peter, Lisa and Romina who are on their way to the 63rd DGP Congress in Düsseldorf! Peter will give a talk on „Interspecies analysis to dissect cellular transcriptomic signatures of humans and hamsters in COVID-19“, Romina on „Experimental investigation of adjuvant therapies in severe pneumonia and ventilation“, while Lisa will present her poster titled „Approaching xeno-free cultivation and utilization of pulmonary pathogens in vitro“

Welcome to our new group member Lisa Pfeiffer, who will be working with Peter Pennitz and Cengiz Gökeri on their Charité 3^R project titled: “Approaching xeno-free cultivation and utilization of pulmonary pathogens in vitro”.

Congratulations to Peter Pennitz and Cengiz Gökeri for being awarded the Charité 3^R grant for “xeno-free in vitro science”! They will be evaluating various commercially available and self-made xeno-free or xeno-reduced alternatives to cultivate Streptococcus pneumoniae that can be used for in vivo and in vitro models of pneumococcal infection.

Congratulations to Sandra-Maria Wienhold and Markus Brack for their work on preclinical assessment of bacteriophage therapy against pulmonary Acinetobacter baumannii infection in mice. Collaborative efforts identified a potential bacteriophage to treat A. baumannii infection in mice with promising implications for future therapeutic development.

Wienhold, S.-M. et al. (2021). Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection. Viruses 14.

Congratulations to Alexander Taylor for the successful defense of his PhD thesis!